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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

TextPride was a fine business, but a tiny one. Meanwhile, the market for messaging apps was exploding. Facebook FB 0.61% bought WhatsApp for $19 billion; that service now has 700 million monthly active users. Tango, an app with 250 million registered users, is worth $1.5 billion. Kik has 200 million registered users. Snapchat, worth $10 billion, has 100 million users. A new study, commissioned by Kik, shows that U.S. users now spend more time on average in messaging apps than they do on social networking apps. The only problem? These messaging apps need ways to make money, and there’s no reasonable way for advertisers to wedge themselves into conversations between friends.
在经历了艰辛的法律诉讼之后,凯莎发表的一切都会给人一种胜利的假象。但这张回归专辑用艺术反映了一位勇士的呐喊,并带来了比所有人期望中更为强大的影响力。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

时间:2011-12-27 编辑:Jasmine
在丝绸之路上找到了一个1700年历史之久的墓地。丝绸之路是一系列的古代贸易路线,曾经链接着中国和罗马帝国。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

到现在第22部007系列片已经登场,邦女郎角色变迁,不过有一点我们可以肯定,无论007电影怎么拍,邦女郎总会漂亮性感、聪明高贵而且越来越有内涵。这是007电影过去、现在乃

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

《速度与激情》则为收入最高的外国影片,位列该榜单的第二位。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Best chance: If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.
7. 《教师》(The Kindergarten Teacher)。在这部严酷、怪异的轰动之作中,以色列导演那达夫·拉皮德(Nadav Lapid)讲述一个教师对一个儿童诗人的迷恋,为狂热及其代价绘制了一幅残忍的肖像。
麻省理工学院斯隆管理学院(MIT Sloan School of Management)教授迈克尔?库苏马诺(Michael Cusumano)表示:“我曾经认为乔布斯是不可取代的,而且这在一定程度上是个事实。但乔布斯的精神依然留存在苹果内部,而且公司正围绕着一种不那么对抗性的文化组织在一起。我们应为此给予蒂姆赞扬。”
The result doesn't look much like a nose—it's a bottle filled with liquid nutrient that cultivates bacteria. But give the “nose” a blood sample and let it sniff for a few days, and the bottle's dots will change color to indicate what bacteria, if any, it identifies.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

9.Carol and Susan's Wedding in Friends
In 2007, Apple released the first iPhone: a full touchscreen phone, complete with its own virtual keypad. To many, Apple had done something new, something never seen before. They had made the first touchscreen phone. But this was incorrect: Apple did not make the first touchscreen phone, nor was the touchscreen a new invention.
In this Jan. 24, 1984, file photo, Steve Jobs, chairman of the board of Apple Computer, leans on the new "Macintosh" personal computer following a shareholder's meeting in Cupertino, Calif
China (mainland and Hong Kong) adds 25 to the list this year, more than any other country, for a total of 207. Three countries debut on the list this year: Mauritius, Slovakia, and Togo.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

The ranking is based on data collected from two surveys: one of the participating business schools and the other of alumni who graduated three years ago — the class of 2013.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Recently, however, the buyback boom has started to fade. The Standard & Poor's 500 Buyback Index, which tracks the 100 companies with the largest share repurchase ratio, recently recorded its first quarterly decline since mid 2012. As stock prices reach record highs, the boost from share repurchases diminishes, making it more valuable for companies to invest in longer-term projects or use extra cash for acquisitions.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

万事达公司表示,其数据反映出世界主要大城市的互联性,并追踪了商务和休闲飞机乘客的消费方式。
如果反弹幅度小、时间短,那么显然结构性变化已经开始了。我希望,过多投资于大成本项目的公司以及仍然高度依赖于油气收入的国家对此做好了准备。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 日系家电告别中国倒计时
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Throughout Downsizing, I kept asking myself what the point of all of this was, never engaged by its hodgepodge of themes. I wish the filmmakers had asked that question too.
We will continue to reform fiscal and tax systems.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Overseas tourists continued to shun Beijing through 2013.
stir

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Songs (Ping An, Xu Yina and Apusasa)
*Guest Actress in a Drama Series: Margo Martindale, “The Americans”
4Germany
用走私野生动物制成的商品到哪里去了?

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 推广“以房养老”保险说易行难
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

魔术队是所有队伍中最迷的哪一个。不论从纸面上看还是从球场表现来看,他们这样的队伍都毫无意义。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Several South Korea-linked entities have already felt Beijing’s wrath in response to the Thaad plans. Chinese state news agency Xinhua last month issued a stark warning to Lotte, one of South Korea’s biggest companies, for giving up land on which the Thaad platform will be hosted.
When asked if the central bank would do more, Dario Perkins, chief European economist at Lombard Street Research, said: “I don’t think so, unless something goes wrong in the wider global economy.”

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 湖南整治不动产登记窗口作风问题
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

《灾难艺术家》一部分是关于好朋友的电影。一部分是娱乐业的新片,还有一部分是幕后的电影短片。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

“授课的是一流从业者,”该学院一名毕业生表示,“该项目为只有极少金融业工作经验的年轻专业人士量身打造,学生们毕业后马上就能投入工作。”

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

2.室内类比赛项目
Denmark, for instance, is 88 percent white Danish today — hardly a majority in jeopardy. But a generation ago, in 1980, it was 97 percent white. The anti-immigrant Danish People’s Party is now the second-largest party in the Danish Parliament. In Germany, where the foreign-born population shot up by approximately 75 percent between 2011 and 2015, the anti-immigrant, populist Alternative for Germany party is now drawing record support.
“What Happened, Miss Simone?” (Liz Garbus)
The Portuguese school has risen 31 places over the past two years since its International Master in Management course was first included in the ranking.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 成本上涨 推动门窗企业变革升级
Review Article

Influenza neuraminidase: A druggable target for natural products

Brands with the most incentive to coast in 2015:Jeep, which must be exhausted after lifting sales an astonishing 44% on the back of the new Cherokee, and Subaru, now the 10th most popular brand in America after improving its sales by 21% in its usual fashion: quietly.
Buyers looking for new construction will have more options next year, as the number of new condos hitting the market in Manhattan, Brooklyn and Long Island City, Queens, is expected to more than double to 8,366 from 3,444 in 2014, according to data provided by Corcoran Sunshine Marketing Group.
"An institution's global outlook is one of the key markers of a prestigious university. The top institutions hire faculty from all over the world, attract students from a global market of top talent and collaborate with leading departments wherever they happen to be based." said Phil Baty, editor of Times Higher Education World University Rankings.
Some 150,000 rural residents in southwest China's Tibet Autonomous Region escaped poverty last year, according to the Tibet Poverty Alleviation Office.
2.《活力王子》中的王子几乎破产

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

'It surprised me, but it's a good sign for Tencent getting abroad, because in particular WeChat is a combination of WhatsApp and Instagram, so it's a unique value proposition that is probably pretty good for emerging market consumers,' he said.
About 40 per cent of entrepreneurs did not seek any help when securing finance. Half of these raised equity purely from their own savings and/or family and friends compared with only 40 per cent of those who sought help from the school or alumni network.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

星期三,2014年春晚主持名单公布,包括了朱军、董卿、毕福剑、李思思和张国立。作为电影演员和导演的张国立会首次主持央视每年举办的春晚。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 27日港股内房板块再度大涨
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

A report from the ministry showed that employers recruited 5.2 million workers through public employment service agencies in the first quarter, dropping 229,000, or 4.5 percent, from the previous year.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Former Disney star-turned-wild child singer Miley Cyrus followed as the number two 'celeb gone good', according to the website. Father-to-be Channing Tatum came in third.
2=中立
We will promote the liberalization and facilitation of international trade and investment.
[tr?ns'p?:t]

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

“我首要的使命、首要的责任是忠实于这本书的原始感觉,忠实于伊恩·弗莱明:他的作品、他的世界和他的构想。
伯利兹城靠近墨西哥和加勒比海,各处都是露天的街头小吃摊,为游客们提供了很多较实惠的用餐选择。
要向依法依规的市场主体发出“前行、前行、再前行”的信号;向依靠劳动创业创新者亮起“可以、可以、再可以”的绿灯;对那些违法违规不良行为,就要及时亮出黄牌,甚至出红牌罚他下场。
据一份全球报告显示,2016年,在富裕国家工作的打工人员往家乡汇款近5000亿美元,通过提供金融稳定、教育机会、住房和医疗保健等来帮助家庭摆脱贫困。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 保定每年5000万元专款引进人才
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

"He promised when he took office that he would have a Cabinet that was 50 percent women, and then he did it," Maddow said. "Would you make that same pledge?"
5. Repeats & highlights are as good as the main match, so am gonna watch them.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

这家Post-it即时贴和思高(Scotch)胶带制造商在2月份授权进行120亿美元的股票回购,取代当前75亿美元的回购计划。《财富》美国500强公司3M公司(3M) 遵循了去年末发表的声明行动。这项声明称,公司在之后4年准备投入100亿美元用于收购,最多将投入220亿美元用于回购。
[?.s?usi'ein]
同时,根据这一最新调查显示,2015年我国男女比例的差距也有所缩小。从性别构成看,男女人口性别比例已由2010年的105.2降至去年的105.02。
5.3-D 打印耳朵
9、邦德经历风险无数却总能死里逃生。当然,人物本身是虚构的。有意思的是,研究证明,肌肉男更皮实。实际上,肌肉不发达对男性来说,可能很要命。(可能就是发达的肌肉让他得以活命的吧,我怀疑他会死于心脏病或前列腺癌)。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

[b?k'ti?ri?]
由于经济增长温和、社会快速老龄化,今年的涨幅较2016年的6.5%有所下降。
斯威夫特今年也收获颇丰,以8千万位居第二。在1989(2014年排名第一的专辑,卖出超过3.6百万份)的发行超过一年后,通过斯科特.伊斯特伍德拍摄的MV,她的最新单曲“最疯狂的梦”一跃成为排行榜第一位。但这只是起始,她的史诗1989世界巡回演唱会最终使她极近收入最高女星榜首。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 2016年橱柜行业三大变化与走势
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

小编碎碎念:华裔球员林书豪的一夜爆红,让因病缺阵的尼克斯当家球星小甜瓜安东尼颇有几分“躺着也中枪”的无辜感。
超过35万的欧洲玩家(还有一些北美和亚洲玩家)带着朝圣般的心情,赶赴人口刚过100万的德国科隆市,参加一年一度的游戏盛会。美国动视(Activision)在展览中首次公布了Sledgehammer Games工作室的多人游戏《使命召唤:高级战争》(Call of Duty: Advanced Warfare),现场玩家亲身体验了这款将于11月3日正式发布的游戏。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 聚焦:十大新型建材走红国内市场
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

At 36, women are about two years younger than men but senior positions are fairly well distributed between genders, with only slightly more women in relatively junior positions — 26 per cent of them are professionals compared with 24 per cent of men.
我是否玩儿得太high了?缺乏实现某些事情的动机会让你失去平衡或者稍后会让你感到筋疲力尽,很有压力。休息一下是非常有必要的,但是如果你休息得过了头从而使生产力降低,或者你养成了太过拖拉的习惯,那么或许就需要时间来平衡你的时间安排,以便你可以完成大量的事情而仍有时间休息娱乐。
当时,身为首席执行官的库克也承受着压力,因为苹果除了从iPhone攫取利润之外,缺乏清晰的产品开发方向。维权投资者嗅到了血腥,开始围攻这家公司,打头的是大卫?艾因霍恩(David Einhorn),接着是卡尔?伊坎(Carl Icahn),他们游说改变苹果的经营和财务管理方式。伊坎施压要求苹果筹集巨额债务,向股东返还1500亿美元,并敦促苹果发布包括电视机在内的更多产品。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 利好!个税抵扣房贷细则出台
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

5.E-Cigarettes
9. Never trust the polls
可穿戴设备公司Atlas Wearables创始人彼得o李表示,电池技术和用户的保守是可穿戴市场面临的两大障碍。他说,在一些情况下,电池技术需要有足够大的改进才能实现足以激发用户兴趣的体验,而在穿戴时间、充电时间、处理能力和产品特点上,各家公司也需要做出平衡。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

反腐力度将会被加强。2014年中国反腐调查案件将会从如今的14万件,增加到超过20万件。这将使得中国更强大。 如果反腐能够成功,将会使中国更关注于做事,而不是搞人事关系。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

The only things in the way are his staff, Republicans in Congress and the limits of his power. And those are important. Campaign promises of 45 per cent tariffs on Chinese goods have turned into investigations into Beijing’s intellectual property regime.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

To put this all in a bit more perspective, the current World Cup is averaging more goals than any of the top leagues around the world averaged in 2013/14. TheNetherlands' Eredivisie was the highest scoring of the top European leagues at 3.20 and the Bundesliga was just a shade behind at 3.16. No other top European league averaged more than 2.80 last season. In theAmericas, Major League Soccer is the current pace setter at 2.89 goals per game.
Together, the world’s 10 highest-paid actresses tallied a combined $205 million between June 1, 2015 and June 1, 2016, before management fees and taxes, Forbes said.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: “双十一”价格战从网上打到线下
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

With interest rates expected to rise only slowly, commodities are likely to attract hedge funds and other speculative investors looking for juicier returns, said the bank.
网红的粉丝也具备年轻化、高学历的特点。在关注网红的用户中,77.8%的人年龄在17-33岁之间,而接受过高等教育的比例达到75%。
但当格雷泽给我们带来《皮囊之下》,这部经过他长期酝酿的,由荷兰作家米歇尔·法柏的科幻小说改编的电影时,真是让人惊叹:欢快,不安,大胆。斯嘉丽扮演的外星人藏于人类的皮囊里,穿梭在格拉斯哥街道和商场,不亚于一位一线明星。现实生活中的路人在镜头中完美的展现,而隐身的约翰森面无表情的估算着三个地球人可被利用的热量值。接着演员带着被色诱的人类离开人群,来到她自己的地方:一个神秘的黑暗的洞穴中。在这里,情色恍惚间,人类贡献自己的肉体,被囚禁,被养殖成为食物,谁知道呢,又或许是人类的灵魂。
恭贺新禧,祝身体健康、事业发达。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

妮妮·切利(Neneh Cherry),《空白计划》(Blank Project), Smalltown Supersound
At school, even in kindergarten, you teach us to behave in the world. You teach us: not to fight with others, to respect others, to clean up our mess, not to hurt other creatures, to share - not be greedy. 在学校,甚至在幼稚园,你们大人教我们如何处世,你们告诉我们不要打架,要尊重对方。找出答案,解决矛盾。去分享,而不是贪婪。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

But that may be overly pessimistic, says Mr Talbot. “Things in Asia do have a habit of moving faster than we think,” he says.
单词neglect 联想记忆:

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

明星们的私家飞机刚停稳,“老爹身材”一词便在互联网上走红。男性微胖的身材成为潮流,荧幕上不少这样的例子。法新社(AFP)Deborah Cole(黛博拉?科尔)写道:“杰拉尔?德帕迪约(Gerard Depardieu)在《爱之谷》中的形象便是“大汗淋漓、气喘吁吁地打着赤膊”, 华金?菲尼克斯 (Joaquin Phoenix)在 伍迪?艾伦(Woody Allen)的新片《非理性的人》(Irrational Man)中也露出了他那胖胖的肚子。科林?法瑞尔(Colin Farrell)出席《龙虾》(The Lobster)的首映红毯时,看起来如往常一般衣冠楚楚,然而在剧中他却大腹便便。为了给荒诞主义者欧格斯?兰斯莫斯(Yorgos Lanthimos)的黑色喜剧中的孤独主角增肥,法瑞尔大量进食高热量食品,其中包括融化了的冰淇淋。他告诉《好莱坞报道》(Hollywood Reporter),“在早晨10点享用2个芝士汉堡、薯条和可乐可不那么有趣,”他补充道,“不过我喜欢芝士汉堡。”

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

这间增加的厨房大约40英尺长(约12米),风格与原建筑保持一致,内有复杂的天花板木制结构和几处由世纪工作室(Century Studios)设计的彩色玻璃板,该工作室是明尼阿波利斯市的一家公司,其玻璃确保来自弗兰克·劳埃德·赖特(Frank Lloyd Wright)曾指定的那家芝加哥制造商。厨房里的不锈钢电器包括一台五英尺宽(约1.5米)的炉灶和一台Sub-zero的冰箱。餐厅区经由10英尺高(约3米)的玻璃门通往屋后的一处露台。
The most sought-after job as of Tuesday remained a position offered by the China Employment Training Technical Instruction Center in Beijing, which had drawn 1,430 applicants, the institute said.
单词institute 联想记忆:
In interviews, everyone works well with others, and everyone learns quickly. Please tell me something else.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

11月份,财新赞助的中国综合PMI指数读数为50.5。这是自7月份以来,该指数首次超过50这个区分收缩和扩张的荣枯线。
不过,五家总部驻北京的旅行社表示,他们仍在销售3月份的韩国游产品,而中国最大在线旅游公司携程(Ctrip)也做了同样表态。中国三大国有航空公司的代表向彭博(Bloomberg)表示,他们并未收到要求停止销售赴韩国机票的指示。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
From the themed collection: 楼市有“紧”才有“稳”
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Baby Driver is so much fun, although it's not necessarily non-stop LOLs, it's definitely non-stop lowercase lols.
The Bellarine Peninsula, located Southwest of Melbourne, Victoria, has been a hotspot for timeless beaches and historic towns like Queenscliff and Portarlington.
n. 紧张,拉紧,血统

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 山西省经济发展信心不断增强
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

6.头戴式电脑出现
《至暗时刻》
The Fate of the Furious was the top-grossing foreign film, ranking second on the list.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

The report notes that China's game developers have been considering subscription models since earlier this year. Among the top 10 games, four are subscription-based titles and two were commercially launched this year, including Shanda Interactive Entertainment Ltd.'s (SNDA) major new title, AION. The Cnzz.com says that a shift to the subscription model would be more likely to create a sense of equity and fairness in the games, because the top players would be those who spend the most time playing, instead of those who spend the most.
The host list of 2014 Spring Festival Gala, including Zhu Jun, Dong Qing, Bi Fujian, Li Sisi and Zhang Guoli, are released on Wednesday. Chinese film actor and director Zhang Guoli will host the annual gala of China Central Television (CCTV) for the first time.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

根据普京最近的一次收入申报,2015年他总计收入大约为890万卢布(约合13.7万美元)。
vi. 领先
PPI已连续下降44个月,反映出建房材料和原料的供应过剩,以及重工业的产能过剩。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

11月17日
将第1题到第9题的分数相加,计算自己在“消极情感”维度的得分。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

No details have been given about the content of the leaflets, though propaganda sent in the past has denounced North Korea's ruling family.
当时,身为首席执行官的库克也承受着压力,因为苹果除了从iPhone攫取利润之外,缺乏清晰的产品开发方向。维权投资者嗅到了血腥,开始围攻这家公司,打头的是大卫?艾因霍恩(David Einhorn),接着是卡尔?伊坎(Carl Icahn),他们游说改变苹果的经营和财务管理方式。伊坎施压要求苹果筹集巨额债务,向股东返还1500亿美元,并敦促苹果发布包括电视机在内的更多产品。
[?d.mini'strein]

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

如今,蓬勃发展的互联网经济在支撑我国信息技术(IT)行业财富增长方面正发挥着越来越重要的作用。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 上海多措并举筹措租赁房源
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Mr Ravenscroft ended up leaving teaching to found Enabling Enterprise, a body that seeks to bridge the gulf between schools and business by taking pupils out of the classroom and giving them practical projects and visits to businesses, including UBS, the bank, and Freshfields, the law firm.
limited

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

当她的妈妈来到学校整理她的遗体时,其他的同学把自己的名字和电话号码给了这个悲伤的女人,要求她联系自己的父母,让他们脱离这个网瘾训练营。网瘾训练营其中一种实践方法就是限制学生与外界接触。它是通过基于恐惧的培训方式和严苟的纪律来“纠正”学生行为的。
Rihanna vs. Rosario Dawson Both stars wore this long satin Dolce & Gabanna dress in different colors.   蕾哈娜和罗莎里奥·道森都穿了这件款式一致颜色不同的D&G

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

HOW MUCH: $1,975,000
荷兰合作银行认为,外汇市场波动性也可能会成为影响未来12个月大宗农产品价格的因素,法国、荷兰和德国大选可能会导致欧元贬值。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

单词shorten 联想记忆:
[i'nili]

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

2.别迷恋哥,哥只是个传说。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 新华社:有序去杠杆 风险可控
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

We will take comprehensive steps to improve product quality.
这是英国影评人参与评选的娱乐性奖项,为在参展影片中表现最精彩的狗颁发纪念奖章。颁奖仪式于上周五(5月22日)在英国展馆举行。今年的金棕榈狗狗奖颁给了一只名叫幸运的狗,它是马耳他梗犬(Maltese terrier)与贵宾犬(Poodle)的混血品种。幸运出现在米古尔?戈麦斯(Miguel Gomes)时长6小时的巨作《一千零一夜》(Arabian Nights)中,在剧中叫做迪克西。幸运的奖品是一只玩具狗骨头,通过视频幸运发表了简短的获奖感言(汪)。但据法新社报道,在这大家其乐融融的时刻,一位法国记者认为在极具魅力的影展间隙举办这样的颁奖仪式真是“英国人愚蠢性格的无端干扰”。“在法国人看来,这有些奇怪,”他在报道中说。“英国人真是不可思议。”
After years working with large consumer product companies like Stride Rite and Keds, Pieri grew frustrated with the difficulty mom-and-pop shops had launching new products. "The more innovative a product—as opposed to mainstream and "known"—the harder it was to get distribution," she explains. In response, she launched The Grommet, a discovery platform that connects customers with inventors' stories and their products, five years ago. Pieri, whose company helped launch products including SodaStream and Fitbit, counts HP CEO Meg Whitman as a mentor and has a side-gig as an entrepreneur in residence at Harvard Business School.
项目管理类

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

当小李子上台领取奖杯时,制片人哈维韦恩斯坦兴奋地拍拍他的背,全场观众起立为他喝彩。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

London Business School is top of the 2014 FT ranking of European business schools, regaining the position it last held in 2005. LBS pushed the 2013 joint winners HEC Paris and Spain’s IE Business School into second and third places respectively.
Iron ore imports fell 12.3 per cent by volume in October from the previous month and 4.9 per cent from the same month a year earlier while coal imports were down 21.4 per cent from September and 30.7 per cent from a year earlier, according to Chinese customs data.
Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

据《每日经济新闻》报道,这16家上市银行计划向股东返还3562亿元现金分红,与前一年相比减少了83亿元。
根据FlightAware网站为福布斯编制的数据显示,总部位于落基山脉以西的航空公司在节假日期间的航班晚点率最低。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 6月建材家居销售同比下跌17%
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

5. Emma Stone
下面就是今年汽车业所经历的高峰和低谷:

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 红星美凯龙抵制天猫双11活动
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

5. Biomedical engineer

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

但是通常你可以选择匿名求职,Fos说,或者要么就拒绝那个选项坚持在领英上面发布,她补充道这样至少更易被招聘者和经理发现。
Four other domestic movies made it to the top ten list, among them are the third winner Never Say Die, Kung Fu Yoga in the fourth place, the fifth winner Journey to the West: The Demons Strike Back, and Youth in the eighth place.
Russian President Vladimir Putin took a 10% pay cut last year, as his country sank into a deep recession. But that was after his salary more than doubled in April 2014, to roughly 9.7 million rubles.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Sometimes bosses suck. But if your boss sucks all the time and takes advantage of your time, it's time to find a new job.
美国演员、作家、时装设计师、舞蹈演员、制片人、歌手——拥有这么多头衔的珍妮弗·洛佩兹是2015年全球十大美女的亚军。作为一个结过三次婚的女星,洛佩兹的感情问题一直都是世界各国媒体关注的焦点。除涉足娱乐圈外,她还在商业领域颇有建树,其中包括经营服装、配饰、香水等。此外,她拥有一家制片公司,主持电视节目,还成立了一家慈善机构。
《胡润百富榜》的编制者胡润(Rupert Hoogewerf,见文首图)表示:“姚振华代表了中国金融投资创造财富的新浪潮。”
节目15 歌曲《甲板上的马头琴》,王宏伟

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

The latest commerce ministry figures do not include real estate purchases by individuals, many of whom exploit loopholes in China's capital control regime to obtain foreign currency. But the foreign exchange regulator has recently moved to close such loopholes, notably by tightening control of forex purchases by individuals, who are allowed to exchange $50,000 worth of renminbi for foreign currency each year.
每个伟大的侦探都需要专属于自己的经典故事。对于福尔摩斯而言,这个故事是《巴斯克维尔的猎犬》。对于阿加莎?克里斯蒂笔下龟毛的比利时侦探赫克尔?波洛而言,这个故事是《东方快车谋杀案》——故事讲述了一个嗜血的恶棍在驶向巴尔干半岛的列车上杀死了一个有钱的商人。真相果真是如此吗?西德尼?吕美特曾在1974年将该故事拍成了一部备受喜爱的电影,强大的演员阵容包括肖恩?康纳利、英格丽?褒曼和阿尔伯特?芬尼(饰演侦探波洛)。如今肯尼思?布拉纳自己戴上了侦探波洛的大胡子,披挂上阵,同时又担当幕后导演。这部新版电影的演员有约翰尼?德普、黛西?雷德利、米歇尔?菲佛、佩内洛佩?克鲁斯和朱迪?丹奇。这个故事还能挖掘出什么新内容呢?也许会有。不过,即使没有,阿婆的粉丝也肯定会去看。这部电影将于11月3日在英国上映,11月10日在美国、中国和土耳其上映,11月30日在中国香港和新加坡上映。(资料来源:二十世纪福克斯电影公司)

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 下半年楼市调控力度或超上半年
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Don't ever tell me that you have to have this job because you're going to lose your house, your kids have nothing to eat, your mother has cancer. Companies aren't a charity.
*剧情类最佳客串女演员:玛格?马丁戴尔(Margo Martindale),《美国谍梦》(The Americans)
尽管谷歌已经竭尽所能,那一刻却依然还未到来。许多报告都声称,可穿戴设备将在2014年成为主流。不过来自数字研究公司L2的最新报告证实了许多人正在默默为之努力的一件事:可穿戴设备仍然没有得到社会的广泛接受,要扩大销量依旧障碍重重。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 广东累计缴存公积金超1.5万亿元
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About this collection

吉密欧(Jamil Anderlini)
After a year of sexual harassment scandals that started in Silicon Valley and spread to just about every industry, women will try to capitalise on the momentum to push for permanent changes. And attention will focus on the plight of marginalised minorities, with so few black and Latino employees in the tech industry.

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